The apo LETM1 F-EF-hand adopts a closed conformation that underlies a multi-modal sensory role in mitochondria.

• Tác giả: Danielle M Colussi, Qi-Tong Lin, Peter B Stathopulos
• Ngôn ngữ: eng
• Ký hiệu phân loại: 025.30285572 Bibliographic analysis and control
• Thông tin xuất bản: England : FEBS letters , 2025
• Bộ sưu tập: NCBI
• ID: 904

Tóm tắt

Leucine zipper EF-hand containing transmembrane protein-1 (LETM1) plays a critical role in mitochondrial function, with haploinsufficiency linked to Wolf-Hirschhorn syndrome. Here, we present the solution NMR structure of the calcium (Ca