BACKGROUND: Non-infectious aortitis encompasses various histological patterns, but their specific cardiovascular outcomes remain unclear. OBJECTIVE: To evaluate the mortality associated with non-infectious surgical thoracic aortitis. METHODS: This retrospective multicenter study included patients who underwent thoracic aortic surgery and had histological evidence of aortitis. The study analyzed the characteristics of patients with non-infectious aortitis presenting either a granulomatous/giant cell histological pattern or a lymphoplasmacytic pattern. Factors associated with mortality were identified using multivariate analysis. RESULTS: Among 5666 patients who underwent thoracic aortic surgery, 197 were found to have non-infectious aortitis with either a granulomatous/giant cell histological pattern (n = 138) or a lymphoplasmacytic pattern (n = 59). The overall standardized mortality rate (SMR) for patients with non-infectious surgical thoracic aortitis was 1.61 (95 % CI: 1.05
2.39), with 31.5 % of patients dying within 10 years of the initial procedure. After a median follow-up of 3.5 years [IQR: 0.5-6.8] post-surgery, 31 % of deaths were due to aortic dissection or rupture. The 10-year cumulative incidence of death was 40.1 % (95 % CI, 17.7-61.8) for patients with a granulomatous/giant cell pattern and 14.4 % (95 % CI, 2.6-35.6) for those with a lymphoplasmacytic pattern. Granulomatous/giant cell histological pattern (HR 4.71 [vs lymphoplasmacytic pattern]
95 % CI, 1.37-16.2
p = 0.023) and aortic dissection at diagnosis (HR 6.07 [vs aneurysm]
95 % CI, 2.89-12.7
p <
0.0001) were independently associated with increased mortality. CONCLUSION: This multicenter study found that 31.5 % of patients with non-infectious surgical thoracic aortitis are expected to die within 10 years of their initial surgery. The granulomatous/giant cell histological pattern is associated with higher mortality.