This paper investigated essential oils (EOs) of the endemic Prangos aricakensis (PA) used as spice and aroma by the Turkish people. Using a Clevenger-type device, EOs were obtained for the first time by hydro-distillation from dried parts of PA (L:leaf, S:stem). The EOs of the PALEO and PASEO were analyzed by GC-MS/MS. The main components of both parts were limonene, bornyl acetate, cinnamic acid ethyl ester, and methyl trans-cinnamate. In this work, enzyme inhibition, antioxidant, antimicrobial, antifungal, and DNA protection activities were applied for PASEO and PALEO. The PALEO in DPPH