Tectona grandis is a Dai medicine that plays an important role in traditional medicine in India, Myanmar, West Africa, and Yunnan Province in China. T. grandis was recorded as an anti-diabetic herb in the Ayurvedic Pharmacopoeia
however, its potential antidiabetic components and possible mechanisms of action have almostly not been described to far. To completely comprehend the pharmacological components and therapeutic potential of T. grandis, we isolated chemical components from the plant's leaves and branches, evaluated their antidiabetic activities, and explored the possible mechanisms of active compounds using molecular docking and network pharmacology. In this study, two new quinones (1-2) and eighteen known compounds (3-20) were isolated and identified from T. grandis. Except for the new quinones 1 and 2, compounds 4, 11-12, 14-15, 18-20 were separated from T. grandis for the first time. The naphthoquinones 1 and 3 showed significant antidiabetic activities in α-glucosidase inhibition assay (IC