BACKGROUND: Epidermoid cysts located completely within the pituitary infundibulum are a rare entity with only 7 reported cases. In this study, we have described our experience with the resection of intra-infundibular epidermoid cysts (IECs) and reviewed the existing literature highlighting its distinguishing features and operative nuances. METHODS: Three consecutive cases of IEC operated at our institute were retrospectively studied. PubMed and EMBASE databases were searched, and 7 case reports of IEC were found. Relevant clinical, radiological, and operative data of 10 cases were analyzed. RESULTS: The median age at diagnosis was 53.5 years, and 6 cases were males. Preoperatively, although the average tumor size was only 1.62 cm CONCLUSIONS: IECs are rare tumors that are often misdiagnosed preoperatively. They have different postoperative morbidity profiles compared to other cystic lesions in the infundibulum. This makes it important to recognize this distinct entity.