Pharmacological characterization of the novel selective kappa opioid receptor agonists 10-Iodo-Akuammicine and 10-Bromo-akuammicine in mice.

• Tác giả: Kathryn Bland, Chongguang Chen, Simone Creed, Conrad Ho, Theodora Howe, Peng Huang, Lee-Yuan Liu-Chen, Joseph Noel-Torres, Katrina Ocampo, Andrew P Riley, Pingwei Zhao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 621.374 Instruments for measuring specific electrical quantities
• Thông tin xuất bản: England : Neuropharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 90806

Tóm tắt

Akuammicine (AKC), an indole alkaloid, is a kappa opioid receptor (KOR) full agonist with a moderate affinity. 10-Iodo-akuammicine (I-AKC) and 10-Bromo-akuammicine (Br-AKC) showed higher affinities for the KOR with K