Genetic correlation, pleiotropic loci and shared risk genes between major depressive disorder and gastrointestinal tract disorders.

• Tác giả: Guo Cheng, Yifan Hu, Xiaoyu Wang, Jingyuan Xiong, Siquan Zhou, Jing Zi
• Ngôn ngữ: eng
• Ký hiệu phân loại: 343.0748 Military, defense, public property, public finance, tax, commerce (trade), industrial law
• Thông tin xuất bản: Netherlands : Journal of affective disorders , 2025
• Bộ sưu tập: NCBI
• ID: 90918

Tóm tắt

 BACKGROUND: Major depressive disorder (MDD) is associated with gastrointestinal tract (GIT) disorders, while genetic correlation, pleiotropic loci and shared risk genes remain to be explored. METHODS: Leveraging genome-wide association study statistics for MDD (n = 170,756), peptic ulcer disease (PUD
  n = 16,666), gastroesophageal reflux disease (GORD
  n = 54,854), PUD and/or GORD and/or medications (PGM
  n = 90,175), irritable bowel syndrome (IBS
  n = 28,518), and inflammatory bowel disease (IBD
  n = 7045), we determined global and local genetic correlations, identified pleiotropic loci, performed gene-level evaluations, and inferred causal associations using bidirectional Mendelian randomization. RESULTS: We found global correlation of MDD with PUD (r CONCLUSIONS: Our work identifies genetic architectures shared between MDD and GIT disorders, contributes genetic insights to understand depression in the context of gut-brain interactions, and provides potential targets to treat gastrointestinal symptoms in depressive patients.