Extracellular vesicles from mesenchymal stem cells improve liver injury in rats with mild liver damage. Underlying mechanisms and role of TGFβ.

• Tác giả: Vicente Felipo, Marta Llansola, Gergana Mincheva, Victoria Moreno-Manzano
• Ngôn ngữ: eng
• Ký hiệu phân loại: 333.92 Air
• Thông tin xuất bản: Netherlands : Life sciences , 2025
• Bộ sưu tập: NCBI
• ID: 90965

Tóm tắt

 Preventing the progression of liver damage to fibrosis would be beneficial for patients with steatotic liver disease (SLD). Mesenchymal stem cells (MSC) are a promising therapy for SLD and derived extracellular vesicles (EVs) could even improve the treatment's efficacy and safety. However, the mechanisms of MSC-EVs beneficial effects are not well known. It has been suggested that modifying the EVs cargo could improve their beneficial effects. The aims of this study were to assess if MSC-EVs reduce liver damage in a rat model of mild liver damage
  to analyze the underlying mechanisms and to assess if silencing TGFβ enhances the beneficial effects of MSC-EVs. CCl