Effect of boswellic acids on the expression of PD-1 and TIGIT immune checkpoints on activated human T cells.

• Tác giả: Ahmed Al-Harrasi, Eyad Elkord, Abdo Meyiah, Najeeb Ur Rehman
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.737 Measures to prevent, protect against, limit effects of pollution
• Thông tin xuất bản: Netherlands : Fitoterapia , 2025
• Bộ sưu tập: NCBI
• ID: 91235

Tóm tắt

Boswellic acids (BAs) have been documented as anti-inflammatory agents with the potential to regulate immune responses. However, their impacts on the expression level of immune checkpoint (IC) molecules in T cells have never been reported. By using flow cytometric assays, we investigated whether BAs extracted from Boswellia sacra (B. sacra) have any potential effects on the expression of PD-1 and TIGIT immune checkpoints (ICs) on activated T cells in vitro. Interestingly β-BA at a concentration of 50 μM significantly reduced the expression of PD-1 and TIGIT on both activated CD4