Analgesic activity of aqueous and methanol fruit pulp extracts of

• Tác giả: Emmanuel A Asongalem, Francis Désiré Bomba Tatsinkou, Georlin E Fotabong, Marius Mbiantcha, Erastus N Nembo, Telesphore B Nguelefack, Armel Jackson Seukep, Bibiane A Wandji, Elisabeth M Zeuko'o
• Ngôn ngữ: eng
• Ký hiệu phân loại: 594.38 *Pulmonata
• Thông tin xuất bản: Germany : Journal of complementary & integrative medicine , 2025
• Bộ sưu tập: NCBI
• ID: 914

Tóm tắt

 OBJECTIVES: Pain affects about one in every five persons and is considered a major global health burden. METHODS: Aqueous (AEHT) and methanol (MEHT) extracts were prepared from fruit pulp of RESULTS: Phytochemical tests revealed saponins, flavonoids, tannins, and phenols. Both extracts greatly decreased the writhing induced by acetic acid. MEHT inhibited both phases of formalin-induced pain (p<
 0.01). Both extracts significantly inhibited hotplate-induced nociception (p<
 0.001), partially reversed by naloxone, except for MEHT. In the capsaicin test, extracts produced a remarkable reduction of paw licking time (p<
 0.01). No motor coordination alteration or acute toxicity effects were observed. CONCLUSIONS: The findings demonstrated the analgesic activity of AEHT and MEHT, mediated by the stimulation of opioids and blockage of vanilloid receptors pathways.