Effects of hypoxia and iron on ascorbic acid-mediated cytotoxicity in prostate cancer cell lines.

• Tác giả: Joseph Bressler, Jonathan Coulter, Samiksha Deme, Channing Paller, Ida Ramezani
• Ngôn ngữ: eng
• Ký hiệu phân loại: 363.737 Measures to prevent, protect against, limit effects of pollution
• Thông tin xuất bản: United States : Toxicology and applied pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 91462

Tóm tắt

Ascorbic acid (ASC) has long been proposed as a potential cancer co-treatment due to its specific toxicity towards cancer cells, but discrepancies between in vitro and in vivo studies suggest that external factors may modulate its cytotoxicity. Here, we investigate the impact of hypoxia and iron on the therapeutic effectiveness of ASC on prostate cancer cell lines. Hypoxia-induced increases in the EC