The role of LAT1 in AOM/DSS-induced colorectal tumorigenesis.

• Tác giả: Misaki Agawa, Takumi Funatsu, Namiko Hoshi, Yuta Inoue, Yoshikatsu Kanai, Yuzo Kodama, Yuna Ku, Haruka Miyazaki, Hirotaka Nakamura, Ryuichi Ohgaki, Norihiro Okamoto, Makoto Ooi, Yunlong Sui, Daisuke Watanabe, Hui Yang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 636.0885 Animal husbandry
• Thông tin xuất bản: United States : Biochemical and biophysical research communications , 2025
• Bộ sưu tập: NCBI
• ID: 91546

Tóm tắt

Amino acid transporters are essential for supplying nutrients to cells and are implicated in tumor progression. L-type amino acid transporter 1 (LAT1) is reported to be overexpressed in various cancers, affecting tumor development. However, the exact mechanisms by which LAT1 affects colorectal cancer (CRC) arising from a chronic inflammatory background are not yet fully understood. This study aimed to explore the role of LAT1 in CRC. Mice with intestinal epithelium-specific deletions of LAT1 (LAT1