Metabolic profiling and antidiabetic potential of Oedogonium angustistomum, Ulothrix variabilis, and Mougeotia pulchella and their peptides targeting α-amylase and α-glucosidase: In vitro and in silico approaches.

• Tác giả: Naiyf S Alharbi, Singamoorthy Amalraj, Edathiruthi Kottukkal Chandran Baiju, Shine Kadaikunnan, Srinivasan Prabhu, Elsa Shibu Sruthy, Rekha Thiruvengadam
• Ngôn ngữ: eng
• Ký hiệu phân loại: 070.48346 Journalism
• Thông tin xuất bản: Netherlands : International journal of biological macromolecules , 2025
• Bộ sưu tập: NCBI
• ID: 93499

Tóm tắt

The present research aimed to examine the diabetes-fighting properties of three algal species: Oedogonium angustistomum, Ulothrix variabilis, and Mougeotia pulchella. The in vitro antidiabetic properties of these algae were investigated by α-amylase and α-glucosidase inhibition assays. The metabolites responsible for the inhibition of α-amylase (2QV4) and α-glucosidase (8YIE) were identified through molecular docking and molecular dynamic simulation in the Maestro V 13.2, Schrödinger suite. In the in vitro research, aqueous, methanol, and petroleum benzene-derived extracts of M. pulchella demonstrated significant inhibition of α-amylase and α-glucosidase, with IC