Gymnema saponin-induced lipid flip-flop identifies rigid membrane phenotype of methicillin resistant S. aureus and enhances it's antibiotic susceptibility.

• Tác giả: Himadri Gourav Behuria, Bijesh Kumar Biswal, Swagatika Dehury, Sasmita Hotta, Ashis Kumar Jena, Indrani Mohanty, Santosh Kumar Padhi, Gayatree Panda, Santosh Kumar Sahu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 005.118 Visual programming
• Thông tin xuất bản: United States : Archives of biochemistry and biophysics , 2025
• Bộ sưu tập: NCBI
• ID: 94152

Tóm tắt

Our previous study revealed that lipid flip-flop inducing phytochemicals from Gymnema sylvestre increase membrane permeability of antimicrobials in S. aureus. However, their lipid flipping and membrane permeabilizing effect on methicillin resistant S. aureus (MRSA) membrane that has intrinsically higher aminoacylated lipid content compared to methicillin sensitive S. aureus (MSSA) is poorly characterized. Gymnema saponins, gymnemic acid I and IV significantly increased the antibiotic susceptibility in both MSSA and MRSA. MRSA exhibited a rigid membrane with lipid diffusion coefficient 0.0002 μm