"Follow the Science" was the cry heard worldwide during the COVID-19 global pandemic. This approach was used to develop evidence-based prevention measures (e.g., social distancing, hand washing, and mask-wearing), COVID treatments, and vaccines and to prevent significant declines in well-being (Donaldson, Cabrera, and Gaffaney, 2021). Leveraging this approach, the study aimed to understand promising ways to disrupt patterns of prejudice and its harmful consequences and identify the most exemplary interventions. The current study systematically reviewed 2515 published peer-reviewed studies included in 13 meta-analyses and systematic reviews on prejudice reduction interventions, using inclusion and exclusion criteria focused on gender and/or race/ethnicity. Phase 1 identified 13 studies, highlighting four exemplary evidence-based approaches: Contact Interventions, Perspective Taking, Interactive and Narrative Modalities, and Multi-faceted Interventions. These approaches presented notable success with the largest effect sizes and should be considered carefully when planning new prejudice reduction efforts. In Phase 2, the study extracted specific interventions from the 13 studies, identifying six specific exemplary interventions for mitigating prejudice and its adverse effects. The study discusses the implications of these findings for program planners and evaluators, suggesting the use of empirical insights to design post-COVID interventions, such as cultural exchange programs, virtual reality experiences, and cross-cultural music initiatives, to create meaningful social changes. Despite these practical insights, the study has limitations, including partial adherence to PRISMA guidelines and the omission of risk of bias assessment for individual studies.