Cerium-doped mesoporous bioactive glass nanoparticles reduce oxidative stress and adipogenic differentiation in human bone marrow-derived mesenchymal stromal cells.

• Tác giả: A R Boccaccini, V Jacobsen, E Kunisch, C Merle, T Renkawitz, F Westhauser, B Xue, K Zheng
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) , 2025
• Bộ sưu tập: NCBI
• ID: 96577

Tóm tắt

Increased levels of reactive oxygen species (ROS) favor adipogenic over osteogenic differentiation in human bone-marrow derived mesenchymal stromal cells (BMSCs). Therefore, biomaterials containing ROS-suppressing elements such as Cerium (Ce) have been introduced to cell-based bone-tissue-engineering (BTE) approaches. This study was conducted to assess the efficacy of Ce-doped mesoporous bioactive glass nanoparticles (MBGNs) in reducing ROS levels and subsequently inhibiting the adipogenic differentiation of BMSCs. To this end, BMSCs were cultivated in adipogenesis inducing medium (AIM) and exposed to ions released from Ce-free MBGNs (composition in mol%: 86SiO