Synthesis and evolution of 16-membered macrolide carrimycin derivatives as a novel class of anti-HCoV-OC43 agents targeting viral FSE RNA.

• Tác giả: Qionglu Duan, Yue Gong, Weiqing He, Hongying Li, Jianrui Li, Jiayu Li, Yinghong Li, Yonghua Liu, Runze Meng, Zonggen Peng, Danqing Song, Zhiyun Wu, Zhihui Yu, Xiuli Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.716 Anti-arrhythmia agents
• Thông tin xuất bản: France : European journal of medicinal chemistry , 2025
• Bộ sưu tập: NCBI
• ID: 96584

Tóm tắt

We first demonstrate that carrimycin, as an antibiotic, shows broad-spectrum anti-coronavirus activity by targeting frameshifting element (FSE) RNA. Herein, taking carrimycin as the lead, 26 new 16-membered macrolides were synthesized and evaluated for antiviral activity against coronavirus strains. Compound 2d exhibited the elevated antiviral efficacy against HCoV-OC43 and HCoV-229E with EC