In recent years, subcritical extraction has developed rapidly due to its environmental friendliness and high efficiency. In the extraction of low-polar and non-polar active substances, the addition of green low-polar solvents to subcritical extraction solvents can increase the yield of active substances. However, solvent screening and extraction conditions prediction are still a challenge. In this study, we employed the Williams formula to incorporate temperature and pressure correction into the Hansen solubility parameter to screen solvent under subcritical conditions by energetic spatial distance R