LGBTQ adolescents and young adults have been disproportionately affected by the COVID-19 pandemic. This review aims to describe the impact of the COVID-19 crisis on mental health among LGBTQ adolescents and young adults, identify associated factors, and summarize coping strategies. A systematic review was conducted by searching six databases (PubMed, Embase, PsycINFO, CINAHL, Web of Science, MEDLINE). Eligibility criteria included (1) reported mental health outcomes, (2) conducted among LGBTQ adolescents and young adults, and (3) data collection occurred since January 2020. All studies were screened independently, and relevant data were synthesized following PRISMA guidelines. Of 395 records, 67 articles were screened for eligibility. Among these, 39 studies met the inclusion criteria. LGBTQ adolescents and young adults reported substantial mental health burdens, including depression, anxiety, stress, and loneliness during the pandemic. A pooled prevalence of depressive symptoms with a combined sample size of 7326 LGBTQ adolescents and young adults was 59% (95%CI: 0.48-0.70), (I