Three new diterpenes from the roots of Salvia miltiorrhiza and their cytotoxicity.

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Tác giả: Lei Fang, Yan-Song Li, Zhe Liu, Yi-Fan Xia, Ping Yu, Jin-Hui Zheng, Jie Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 006.693 Three-dimensional graphics

Thông tin xuất bản: Netherlands : Fitoterapia , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 96796

Two undescribed oxazole-containing diterpenoids (1-2) and a new diterpenoid (3) were isolated from the roots of Salvia miltiorrhiza. Their structures were elucidated by extensive HRESIMS and NMR spectroscopic analysis, and the absolute configurations of 1 and 3 were confirmed by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Compound 1 represents the first example of an abietane diterpenoid with a benzo[d]oxazole unit fused in the ring B of the abietane skeleton. The cytotoxicity of 1-3 was evaluated against four human tumor cell lines (A549, MCF-7, HepG2, and PC-3), and 1-2 showed weak cytotoxic activities.
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