INTRODUCTION: The functions of S1P receptors have been revealed using genetic and pharmacological tools, including the potent non-selective modulator FTY720. However, studies on subtype-specific agonists and antagonists are limited
hence, the role of S1P OBJECTIVES: To identify a novel function of S1P METHODS: Heteroaromatic analogs of FTY720 were synthesized, a β-arrestin assay was conducted against S1P receptors, and the developed compound (NXC736) was characterized as a functional S1P RESULTS: Molecular modeling studies provide valuable clues for understanding S1P CONCLUSION: Using a functional S1P