BACKGROUND: Human brain connectivity can be measured in different ways. Intracranial EEG (iEEG) measurements during single pulse electrical stimulation provide a unique way to assess the spread of electrical information with millisecond precision. However, the methods used for the detection of responses in cortico-cortical evoked potential (CCEP) data vary across studies, from visual inspection with manual annotation to a variety of automated methods. NEW METHOD: To provide a robust workflow to process CCEP data and detect early evoked responses in a fully automated and reproducible fashion, we developed the Early Response (ER)-detect toolbox. ER-detect is an open-source Python package and Docker application to preprocess BIDS structured iEEG data and detect early evoked CCEP responses. ER-detect can use three early response detection methods, which were validated against 14 manually annotated CCEP datasets from two different clinical sites by four independent raters. RESULTS: and comparison with existing methods: ER-detect's automated detection performed on par with the inter-rater reliability (Cohen's Kappa of ~0.6). Moreover, ER-detect was optimized for processing large CCEP datasets, to be used in conjunction with other connectomic investigations. CONCLUSION: ER-detect provides a highly efficient standardized workflow such that iEEG-BIDS data can be processed in a consistent manner and enhance the reproducibility of CCEP based connectivity results for both research and clinical purposes.