Estrogens play an important role in the regulation of female social recognition
however, their mechanisms have not yet been elucidated. The present study established a mouse model of adolescent ovariectomy (Ovx) supplemented with a physiological dose of estradiol benzoate (EB, 10 µg/kg). Familiar-novel individual identification, urine odor discrimination, and social memory behaviors were assessed after adulthood. The results showed that Ovx-induced impairment of individual identification, urine odor discrimination, and social memory 24 h after testing were significantly improved by EB supplementation. Meanwhile, EB restored 17β-estradiol (17β-E