Liver specific transgenic expression of CYP7B1 attenuates early Western diet-induced MASLD progression.

• Tác giả: Nanah Bai-Kamara, Sudha Biddinger, Michael Fuchs, Genta Kakiyama, Kei Minowa, Tsuyoshi Murai, Hiroshi Nittono, William M Pandak, Daniel Rodriguez-Agudo, Arun Sanyal, Mark A Subler, Mitsuyoshi Suzuki, Hajime Takei, Jolene J Windle
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Journal of lipid research , 2025
• Bộ sưu tập: NCBI
• ID: 97782

Tóm tắt

Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. Among various hepatic genes impacted during MASLD development, CYP7B1 is consistently suppressed in multiple MASLD mouse models and in human MASLD cohorts. CYP7B1 enzyme suppression leads to accumulations of bioactive oxysterols such as (25R)26-Hydroxycholesterol (26HC) and 25-hydroxycholesterol (25HC). We challenged liver specific CYP7B1 transgenic (CYP7B1