A non-hydrolysable peptidomimetic for mitochondrial targeting.

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Tác giả: Yeray Folgar-Cameán, Patricia Fulias-Guzmán, Ona Illa, Irene Máximo-Moreno, Javier Montenegro, Marta Pazo, Miriam Royo, Daniel Torralba-Maldonado

Ngôn ngữ: eng

Ký hiệu phân loại: 220.12 Canon

Thông tin xuất bản: England : Journal of materials chemistry. B , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 9787

Peptidomimetics, molecules that mimic the activity of natural peptides with improved stability or bioavailability, have emerged as interesting materials with applications in biomedicine. In this study, we describe a hybrid γ,γ-peptidomimetic that efficiently aims at mitochondria, a key therapeutic target associated with several disorders, in living cells. Peptide backbones with a component of cationic and hydrophobic amino acids have been shown to preferentially target mitochondria due to their high negative membrane potential and hydrophobic character of the membranous invaginations of these key organelles. We here exploit the advantageous bioorthogonal properties of a peptidomimetic scaffold that consists of an alternation of (1
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