A pair of undescribed enantiomers of phenolic compound bearing a rare oxetane moiety, (±)-vachanin L ((±)-1), and an undescribed monoterpene, vachanin M (2), along with fifteen known compounds including a monoterpene (3), a diterpene (4), seven flavonoids (5-11) and six lignan analogs (12-17) were isolated from the aerial parts of Artemisia vachanica Krasch. ex Poljakov. Their structures were identified based on HR-ESI-MS and NMR spectroscopy techniques. Relative configuration of vachanin L (1) was established by