A general framework to analyze potential roles of tDRs in mammalian protein synthesis.

• Tác giả: Nupur Bhatter, Pavel Ivanov
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Methods in enzymology , 2025
• Bộ sưu tập: NCBI
• ID: 98875

Tóm tắt

tRNA-derived RNAs (tDRs) are a heterogeneous class of small non-coding RNAs that have been implicated in numerous biological processes including the regulation of mRNA translation. A subclass of tDRs called tRNA-derived stress-induced RNAs (tiRNAs) have been shown to participate in translational control under stress where specific tiRNAs repress protein synthesis. Here, we use a prototypical tiRNA (5'-tiRNA