TGIRT-seq to profile tRNA-derived RNAs and associated RNA modifications.

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Tác giả: Monima Anam, Anindya Dutta, Abigail Grace Johnston, Zhangli Su

Ngôn ngữ: eng

Ký hiệu phân loại:

Thông tin xuất bản: United States : Methods in enzymology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 98886

RNA modifications are key regulators for RNA processes. tRNA-derived RNAs are small RNAs with size between 15 and 50 bases long that are processed from mature or precursor tRNAs. Despite their more recent discovery, tRNA-derived RNAs have been found to play regulatory roles in many cellular processes including gene silencing, protein synthesis, stress response, and transgenerational inheritance. Furthermore, tRNA-derived RNAs are highly abundant in bodily fluids, posing as potential biomarkers. A unique feature of tRNA-derived RNAs is that they are rich in RNA modifications. Many of the RNA modifications on tRNA-derived RNAs disrupt Watson-Crick base pairing and will thus stall reverse transcriptase, such as N
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