Unveiling the cyclopropyl appended acyl thiourea derivatives as antimicrobial, α-amylase and proteinase K inhibitors: Design, synthesis, biological evaluation, molecular docking, DFT and ADMET studies.

• Tác giả: Hammad Ismail, Muhammad Rashid, Aamer Saeed, Hina Zaman
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Archives of biochemistry and biophysics , 2025
• Bộ sưu tập: NCBI
• ID: 99063

Tóm tắt

Acyl thiourea scaffolds are frequently employed in drug development to discern unique and essential therapies for the eradication of the most challenging diseases. Hence, we developed a library of novel cyclopropyl incorporating acyl thiourea derivatives (4a-j) and evaluated their antimicrobial, α-amylase, and proteinase K inhibition potential. Compound (4h) (4-methoxy) demonstrated the strongest α-amylase inhibition (IC