ZLN005, a PGC-1α agonist, delays photoreceptor degeneration by enhancing mitochondrial biogenesis in a murine model of retinitis pigmentosa.

• Tác giả: Chengyu Hu, Lei Jiang, Tingting Li, Ruoyi Lin, Yunhong Luo, Yaoyan Qiu, Chengda Ren, Tianyi Shen, Tu Su, Zhongqi Wan, Yan Wu, Donghui Yu, Jing Yu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 579.5654 Fungi Eumycophyta (True fungi)
• Thông tin xuất bản: England : Neuropharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 99275

Tóm tắt

Retinitis pigmentosa (RP) is a hereditary neurodegenerative disease characterized by the degeneration of photoreceptors caused by mutations in various genes. Increasing evidence suggests that mitochondrial biogenesis plays a critical role in many neurodegenerative diseases. This study investigated the role of mitochondrial biogenesis in rd1 mice, a widely recognized model of RP. Male C57BL/6 mice and age-matched rd1 mice were used for in vivo experiments, while H