Galloylated polyphenols represent a new class of antithrombotic agents with broad activity against thiol isomerases.

• Tác giả: Roelof H Bekendam, Robert Flaumenhaft, Emmy Fulcidor, Ionita C Ghiran, Shihui Guo, Quinn P Kennedy, Oren Levy, Lin Lin, Glenn Merrill-Skoloff, Osamede C Owegie, Anika Patel, Kelsey D Sack, Christina Scartelli, Huanzhang Xie, Moua Yang, Ivan Hancco Zirena
• Ngôn ngữ: eng
• Ký hiệu phân loại: 936 Europe north and west of Italian Peninsula to ca. 499
• Thông tin xuất bản: England : Journal of thrombosis and haemostasis : JTH , 2025
• Bộ sưu tập: NCBI
• ID: 99363

Tóm tắt

BACKGROUND: Both protein disulfide isomerase (PDI) and SARS-CoV-2 main protease (M AIMS: Our goal was to identify phytochemical inhibitors of SARS-CoV-2 M METHODS: PDI, ERp57, ERp5, ERp46, isolated domains of PDI, and PDI mutants were used to evaluate effects of galloylated polyphenols and their analogs on thiol isomerase reductase activity. Laser-injury and FeCl RESULTS: Pinocembrin 7-O-(3''-galloyl-4'',6''-(S)-hexahydroxydiphenoyl)-beta-D-glucose (PGHG) inhibited both PDI and SARS-CoV-2 M CONCLUSIONS: Galloylated polyphenols represent a large class of antithrombotic compounds with broad activity against thiol isomerases. Many of these compounds also inhibit SARS-CoV-2 M