Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-Versus-Host Disease Survivorship After Hematopoietic Cell Transplantation: Part III. Long-term Impact of Chronic GVHD on Endocrinologic, Cardiovascular, and Metabolic Outcomes in Survivors of Pediatric HCT.

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Tác giả: Geoffrey D E Cuvelier, Chrisitne Noel Duncan, Jonathan D Fish, Lev Gorfinkel, Gregory M T Guilcher, Jonathan Howell, Pooja Khandelwalhl, Miki Nishitani, Brandon Nuechterlein, Esther Obeng, Seth Rotz, Ami J Shah, Kirsten M Williams

Ngôn ngữ: eng

Ký hiệu phân loại: 636.0885 Animal husbandry

Thông tin xuất bản: United States : Transplantation and cellular therapy , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 99447

Chronic graft-versus-host disease (cGVHD) has profound impact on the endocrinologic and cardiovascular health of survivors of transplantation performed in childhood. The impact of cGVHD is long-lasting and contributes to morbidity and early mortality through multiple mechanisms. Organs and tissue may be direct targets of alloreactive donor derived immune cells. Corticosteroid and other cGVHD-directed therapies influence hormonal actions, alter bone metabolism, and negatively impact cardiometabolic health. Pediatric survivors are particularly vulnerable to the endocrinologic and cardiovascular effects of cGVHD as it develops during periods of intense growth and development, though little is known about the direct contribution to late effects. The Research and Education towards Solutions for Late effects to Innovate, Excel, and Nurture after cGVHD (RESILIENT after cGVHD) brought together content experts to determine the state of the science, develop clinical recommendations, and to set a propose a research agenda in endocrine, cardiovascular, and metabolic cGVHD survivorship, which are detailed in this report.
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