Patient-centered communication (PCC) plays a pivotal role in improving healthcare quality and health outcomes. A plethora of cancer prevention-related information is publicly available, potentially leading to cancer information overload (CIO). However, little is known about whether experience with PCC can help prevent or reduce CIO among adults without a history of cancer. Pooled data from the Health Information National Trends Survey (HINTS 5, Cycles 1-4, 2017 through 2020) were utilized for 10,636 non-institutionalized U.S. adults (≥18 years) without a history of cancer. The CIO was constructed based on respondents' experiences of difficulties following myriad cancer prevention recommendations. Experience of PCC was measured on a composite score scale of 0 to 100 based on elements of the PCC model for patient-healthcare provider encounters. A multivariable logistic regression model was fitted to investigate associations between PCC and CIO. Approximately 75.0% of the study respondents with a lower mean PCC expressed experiencing CIO (79.1 vs. no-CIO = 82.1,