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11-20 trong số 235 kết quả
Impact of Fluorine Pattern on Lipophilicity and Acid-Base Properties of 2-(Thiofluoroalkyl)pyridines: Insights from Expe...
Tác giả: Miguel Bernús, Gonzalo D Núñez, Will C Hartley, Marc Guasch, Jordi Mestre, Maria Besora, Jorge J Carbó, Omar Boutureira
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  691.96
 
Rational Design and Optimization of a Potent IDO1 Proteolysis Targeting Chimera (PROTAC)
Tác giả: Paige J Monsen, Prashant V Bommi, Michael Egozi, Sonam Jha, Sara F Dunne, Hong Jiang, Guiqin Song, Fang Zhang, Steven Kregel, Ali Vaziri-Gohar, Sean W Fanning, Pilar Sanchez-Gomez, Arabela A Grigorescu, Jacob M Allen, Bakhtiar Yamini, Rimas V Lukas, Derek A Wainwright, Gary E Schiltz, Kristen L Lauing, Yingyu Mao, Payton Berardi, Lijie Zhai, Oluwatomilayo Ojo, Manon Penco-Campillo, Taylor Koch
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  912.01
 
Design, Synthesis, and Characterization of GluN2A Negative Allosteric Modulators Suitable for In Vivo Exploration
Tác giả: François P Bischoff, Sven Van Brandt, Celine Schalk-Hihi, Robyn Miller, David Duda, Paul Shaffer, Scott Ballentine, Sirak Simavorian, Brian Lord, Robert A Neff, Pascal Bonaventure, Harrie J M Gijsen, Marcel Viellevoye, Michel De Cleyn, Michel Surkyn, Rodrigo J Carbajo, Maria Dominguez Blanco, Berthold Wroblowski, Nathan K Karpowich, Ruth A Steele
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  296.123
 
Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists
Tác giả: Brian S Gerstenberger, Ray Unwalla, Gary M Chinigo, Andrew Flick, Neelu Kaila, Daniel Lamb, James J Mousseau, Nootaree Niljianskul, Mathieu Rappas, John I Trujillo, Michael L Vazquez, Atli Thorarensen, Kathleen A Farley, Mark E Schnute, Philippe Nuhant, Vincent M Lombardo, Wei Li, Kimberly Crouse, Richard K Frisbie, Eric P Arnold, Mark W Bundesmann
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc: 
 
Design, Synthesis, and Biological Evaluation of BODIPY-Caged Resiquimod as a Dual-Acting Phototherapeutic
Tác giả: Eslam Roshdy, Haruto Taniguchi, Yoki Nakamura, Haruko Takahashi, Yutaka Kikuchi, Ismail Celik, Elsayed S I Mohammed, Yasuhiro Ishihara, Norimitsu Morioka, Manabu Abe
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  382.091
 
Discovery of GJG057, a Potent and Highly Selective Inhibitor of Leukotriene C4 Synthase
Tác giả: Gebhard Thoma, Wolfgang Miltz, Ayako Honda, Ritesh Tichkule, Xin Chen, Tajesh Patel, Nancy Labbe-Giguere, Kian L Tan, Clayton Springer, John Manchester, Andrew J Culshaw, Peter Hunt, Rudolf Waelchli, Honnappa Srinivas, Carlos A Penno, Sandrine Ferrand, Shin Numao, Ulrich Schopfer, Petra Jäger, Nathalie Wack, Franziska Hasler, Beatrice Urban, Miriam Sindelar, David Orain, Pius Loetscher, Michael Kiffe, Xiaojun Ren, Paul Nicklin, Kevin White, Khaushik Subramanian, Haoyuan Liu, Ellena J Growcott, Till A Röhn, Carsten Spanka, Odile Decoret, Romain M Wolf, Brian Hurley, Atwood K Cheung, David A Sandham
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc: 
 
Development of a Novel Human Serum Albumin-Based Tool for Effective Drug Discovery: The Investigation of Protein Quality...
Tác giả: Balázs Kenéz, Gábor Koplányi, Balázs Decsi, Zsófia Molnár, Péter Horváth, Gábor Katona, György T Balogh, Diána Balogh-Weiser
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  781.726
 
Structure-Based Optimization of Pyridone α-Ketoamides as Inhibitors of the SARS-CoV-2 Main Protease
Tác giả: Ravi Kumar Akula, Haifa El Kilani, Burhan Karadogan, Dirk Jochmans, Johan Neyts, Katharina Rox, Rolf Hilgenfeld, Mark Brönstrup, Alina Metzen, Judith Röske, Kaixuan Zhang, Matthias Göhl, Nanaji Arisetti, Graham P Marsh, Hannah J Maple, Mark S Cooper
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  781.726
 
Discovery of (3-Phenylcarbamoyl-3,4-dihydro-2
Tác giả: Andrea Bagán, Alba López-Ruiz, Luis F Callado, José M Entrena, Enrique J Cobos, Belén Pérez, José A Morales-García, Elies Molins, Steven De Jonghe, Dirk Daelemans, José Brea, Cristina Val, Sònia Abás, M Isabel Loza, Elena Hernández-Hernández, Jesús A García-Sevilla, M Julia García-Fuster, Caridad Díaz, Rosario Fernández-Godino, Olga Genilloud, Milan Beljkaš, Slavica Oljačić, Katarina Nikolic, M Carmen Ruiz-Cantero, Carmen Escolano, Foteini Vasilopoulou, Teresa Taboada-Jara, Christian Griñán-Ferré, Mercè Pallàs, Carolina Muguruza, Rebeca Diez-Alarcia
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc: 
 
Discovery of Small Molecules that Bind to Son of Sevenless 2 (SOS2)
Tác giả: Krzysztof M Zak, Alex G Waterson, Jianwen Cui, Jason Phan, Jason R Abbott, Dhruba Sarkar, Timothy R Hodges, Allison Arnold, John L Sensintaffar, Stephen W Fesik, Dirk Kessler, Leonhard Geist, Nina Braun, Katja Hauer, Klaus Rumpel, Juergen Ramharter, Heinz Stadtmueller, Bernhard Wolkerstorfer, David Schoenbauer
Xuất bản: United States: Journal of medicinal chemistry , 2025
Bộ sưu tập: NCBI
ddc:  271.6
 

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