Single-particle cryo-EM of biological macromolecules

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Tác giả: Wah Chiu, Robert M Glaeser, Eva Nogales

Ngôn ngữ: eng

ISBN-13: 978-0750330374

ISBN-13: 978-0750330381

ISBN-13: 978-0750330398

ISBN-13: 978-0750330404

Ký hiệu phân loại: 574.19283 [Unassigned]

Thông tin xuất bản: Bristol [England] (Temple Circus, Temple Way, Bristol BS1 6HG, UK) : IOP Publishing, 2021

Mô tả vật lý: 1 online resource (various pagings) : , illustrations (some color).

Bộ sưu tập: Tài liệu truy cập mở

ID: 161007

This edited book is written for students, postdocs and established investigators who want to enter the field of single-particle cryo-EM. This is a recently developed method to determine high-resolution structures of biological macromolecules. A major strength is the fact that cryo-EM does not require prior crystallization of protein complexes. It is especially well suited for larger complexes and molecular machines. This book provides a comprehensive, accessible and authoritative introduction to the field. It covers all necessary background, ranging from the underlying concepts to practical aspects such as specimen preparation, data collection, data analysis, and the final validation of results.
Includes bibliographical references.
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