The two-volume set LNBI 11465 and LNBI 11466 constitutes the proceedings of the 7th International Work-Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2019, held in Granada, Spain, in May 2019. The total of 97 papers presented in the proceedings, was carefully reviewed and selected from 301 submissions. The papers are organized in topical sections as follows: Part I: High-throughput genomics: bioinformatics tools and medical applications
omics data acquisition, processing, and analysis
bioinformatics approaches for analyzing cancer sequencing data
next generation sequencing and sequence analysis
structural bioinformatics and function
telemedicine for smart homes and remote monitoring
clustering and analysis of biological sequences with optimization algorithms
and computational approaches for drug repurposing and personalized medicine. Part II: Bioinformatics for healthcare and diseases
computational genomics/proteomics
computational systems for modelling biological processes
biomedical engineering
biomedical image analysis
and biomedicine and e-health. .